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During unsettled economic times, drug developers must deal with elevated levels of uncertainty when allocating their precious research resources. As pressure grows to reduce overhead and streamline operations, managers must make hard choices about which tasks are truly core. With manpower limited, or even reduced, how can departments continue to push forward in achieving their research objectives?
Cell culture services is a labor-intensive operation that merits careful evaluation. Leaders need to ask if their limited personnel should be dedicated to high value activities that lead to new, important, and profitable discoveries; or should their time be spent on lower value, but necessary, work, such as growing cells.
Outsourcing cell culture can offload activities such as growing, harvesting, Mycoplasma testing and more. While outsourcing represents an expense, it is one that can be turned off or on as needed, eliminating the need to carry excess staff to satisfy peak activity periods.
When evaluating an outsourcing strategy, it is important to take a comprehensive look at the internal expense categories and other considerations involved in in-house cell culture operations. These can include:
Cell Growth/Scale-Up Operations
- Reagents and media inventory management and procurement
- Lab and equipment prep
- Accessing frozen cells (internally or externally)
- Cell Thawing
- Pre-Myco Testing to ensure cells are clean
- Scale-up Operations
- Multiple cycles of refeed and passage/split to larger vials
- Replace media
- Count Cells
- Check Viability
- Documentation of each step
- QC sampling when scale is achieved
- Spin down cells/Aliquot (Spin down, Labeling, Capping, Step-wise freeze process, Transfer to storage)
- Clean-up and documentation
- Management time to oversee, train, support, troubleshoot operations
- Consumables and direct costs (Media, Feed, Vials, Labels, Boxes for storage, LN2 cost for freeze-down)
QC Activities
- Per Batch QC (internal labor and materials or external lab cost)
- Lab QC, such as weekly swabs of hoods, other equipment
Storage/Inventory Management
- Space and overhead
- Manpower to manage, pull samples
- Cost of lost/misplaced samples
Overhead & Maintenance
- Lab Space
- Equipment
a. Incubators
b. Freezers
c. Refrigerators
d. Laminar Flow Hoods
e. Water Baths
f. Cell Counter
g. Centrifuge?
h. LN2 tanks
i. Flow Cytometry
Risk Mitigation
- Cost and impact of contamination/Batch Failure
- Equipment Failure
Other Considerations
- Operating Flexibility
a. Can intensify operations without adding staff (scale-up production to meet demand)
b. Can de-intensify operations without worrying about underutilizing or cutting staff
c. Can adjust start times for batches on demand - Start-Up time (external can start faster/less ramp-up time)
- Opportunity Cost (staff can focus on higher-value activities)
- Staffing/HR Costs (Eliminate hiring, training, turnover)
Obviously, high quality cells are essential for much of bioscience discovery, but who should be investing most of their time growing cells for experiments and drug screening? Should it be scientists who are focused on delivering high value discoveries? The answer is clearly no. Highly trained researchers’ time and talents should not be expended on labor intensive non-core activities. It makes far more sense to delegate these activities to an organization, such as ABS Bio, that exists to free researchers to do research rather than reagent preparation.
ABS Bio has over three decades of experience and expertise in providing cost-effective custom biological reagents for research, such as ready-to-use cells, cell banks, cell membrane preparations, and a large variety of other services. For example, we offer cell bank cryostorage, cell line ID, DNA and RNA extractions, protein extractions, transfections, cell-sorting, and flow cytometry cell QC and phenotyping. Our cell culture operation is scaled to be much more efficient that a typical in-house lab can be, resulting in lower cost per batch.
ABS Bio is your long-term lab partner, but ABS is a not a fixed line item on your budget. We are there when you need us, and you are in control of how much we do for you as your needs change. To learn more, please visit our website and contact us.

HARMINDER SINGH, M.D.
Business Development Director, ABS Bio
15+ years in life sciences
Biospecimen operations expert
Precision medicine research
Harminder Singh, M.D. is Business Development Director at ABS Bio. He joined ABS Bio from Cureline, where he was instrumental in leading biospecimen operations. He brings more than 15 years of experience in the life sciences industry and is a recognized expert in human biospecimen sourcing, management, and global clinical research. Dr. Singh is actively engaged in designing and executing research projects involving human biospecimens to help develop precision medicine therapies. He has a strong track record of building and maintaining long-term partnerships with clinical networks and pharmaceutical/biotechnology clients.