The journey from initial drug discovery to clinical application is full of challenges, especially during the pre-clinical phase. This critical stage, where potential drug candidates are rigorously tested for efficacy and safety, is essential for identifying viable therapies before they reach human trials. Despite its importance, pre-clinical drug discovery is often hampered by various bottlenecks that can impede progress and inflate costs. In this blog, we will explore common bottlenecks in pre-clinical drug discovery, their impact, and potential strategies to overcome them.