Multiplex Immunofluorescence (IF), FISH & Spatial Biology Services

ABS Bio provides Immunofluorescence (IF), Fluorescence In Situ Hybridization (FISH), and multiplex spatial biology services to support translational research, biomarker discovery, precision medicine, and drug development programs. These advanced tissue analysis techniques enable high-resolution visualization of proteins, nucleic acids, and cellular interactions within complex tissue environments, providing valuable insights into tissue architecture, biomarker distribution, and cellular relationships.

From single-marker detection to complex multiplex spatial profiling studies, ABS Bio helps researchers characterize biological systems within their native tissue context. Our services support a wide range of applications, including immuno-oncology research, companion diagnostic development, translational research, and cell and gene therapy programs.

Immunofluorescence enables visualization of protein expression within tissues using fluorescently labeled antibodies. ABS Bio offers both single-plex and multiplex staining approaches to support biomarker characterization and tissue-based research.

Capabilities include:

• Single-plex fluorescent staining
• Multiplex fluorescent staining
• Staining protocol optimization
• Assay development and optimization

FISH provides a powerful approach for visualizing and analyzing nucleic acid targets directly within tissue samples. ABS Bio supports a variety of FISH-based applications designed to evaluate genetic and chromosomal alterations.

Capabilities include:

• Detection of gene amplification, deletion, and translocation events
• RNA probe-based assays
• DNA probe-based assays
• Chromosomal abnormality analysis
• Copy number variation studies
• Custom probe validation and optimization

Multiplex spatial biology approaches enable simultaneous visualization of multiple biomarkers within a single tissue section, helping researchers better understand cellular interactions and tissue organization.

Capabilities include:

• Simultaneous visualization of multiple biomarkers
• Spatial biology and cell interaction analysis
• Tumor microenvironment mapping
• Immune-oncology profiling
• Custom multiplex panel development

ABS Bio supports advanced imaging and analysis workflows that help transform tissue staining data into actionable research insights.

Capabilities include:

• Whole-slide fluorescence imaging
• Quantitative image analysis
• Data integration for translational research studies

ABS Bio’s IF, FISH, and multiplex spatial biology services support a broad range of biomedical research applications, including:

• Spatial biology and tissue architecture analysis
• Immuno-oncology research
• Precision medicine and biomarker discovery
• Companion diagnostic development
• Cell therapy and gene therapy research
• Translational and clinical research studies